Pharm Ingredients
L Carnosine Powder
What Is L Carnosine Powder?
Kintainutri® manufactures l carnosine powder with a purity specification of 98–99%. We specialize in the R&D and production of high-purity, natural active ingredients, empowering our global clients to efficiently develop high-quality products. Carnosine is a dipeptide synthesized from beta-alanine and L-histidine, and it is widely distributed throughout the human brain, muscles, and gastrointestinal tract. It exhibits potent antioxidant properties, effectively scavenging reactive oxygen species and toxic aldehydes, inhibiting glycation reactions, and chelating metal ions.
L carnosine powder helps protect renal cells and delay the aging process. Furthermore, its constituent beta-alanine can elevate muscle carnosine levels and enhance athletic performance, making it a popular ingredient in supplements for athletes. Thanks to its exceptional biological activity, Carnosine has become a highly sought-after product within the extracts industry. Should you require further details, we invite you to contact us for a consultation.
| Product Name | Source | Best-selling Specifications |
|---|---|---|
| L Carnosine Powder | Synthesis | |
| 98% | ||
| 99% |
| Item | Specification | Test Methods |
|---|---|---|
| Appearance | White Crystalline Powder | Organoleptic |
| Odor & taste | Characteristic | Organoleptic |
| Mesh size | Through 80 mesh | 80 mesh screen |
| Assay | ≥98.0% | HPLC |
| Loss on Drying | ≤5.00% | Drying Method |
| Total Plate Count | ≤1000 cfu/g | Bacterial culture |
| Total Yeast & Mold | ≤100 cfu/g | Bacterial culture |
| E.Coli | Negative | Bacterial culture |
| Salmonella | Negative | Bacterial culture |
| Staphylococcus | Negative | Bacterial culture |
How To Make L Carnosine Powder?
L Carnosine Powder Benefits
L-carnosine for autism recovery and ADHD
L carnosine powder demonstrates efficacy in both autism and ADHD. In individuals with autism, the mTOR pathway is hyperactivated within the prefrontal cortex and amygdala; this leads to enhanced phosphorylation of downstream proteins, which in turn triggers social and behavioral abnormalities. Carnosine acts to block this pathway by reducing the phosphorylation levels of mTOR, Akt, and p70S6K. Furthermore, a histidine-rich diet has been shown to alleviate autism-like behaviors.
Consequently, by modulating the mTOR signaling pathway, carnosine ameliorates the social, communication, and behavioral symptoms associated with autism. Additionally, when administered as an adjunctive therapy to Ritalin (methylphenidate), Carnosine has been shown to improve clinical symptoms, particularly those related to inattention, in children with ADHD who had not previously received medication.
L carnosine benefits for skin
Carnosine effectively delays skin aging and promotes wound healing by mitigating oxidative damage, specifically by reducing lipid peroxidation and enhancing the activity of antioxidant enzymes, while also stimulating keratinocyte proliferation and migration and accelerating epithelial-mesenchymal transition and re-epithelialization. Furthermore, carnosine counteracts D-galactose-induced glycation damage and reduces the accumulation of Advanced Glycation End-products (AGEs). Kintainutri®’s L-Carnosine exerts a dual effect by combating aging and promoting wound healing through its antioxidant and anti-glycation properties, as well as its modulation of the PI3K/Akt signaling pathway. It is suitable for use in anti-aging cosmetics and medical wound care products.
Anti-Glycation Effects
Carnosine exhibits significant immunomodulatory activity, effectively reducing the levels of various pro-inflammatory cytokines (such as IL-6, TNF-α, and IL-8). In diabetic models, l carnosine powder inhibits the elevation of inflammatory factors and ameliorates insulin resistance; regarding gut health, it mitigates inflammatory responses associated with inflammatory bowel disease. Furthermore, carnosine demonstrates potential hepatoprotective and neuroprotective properties, lowering inflammation levels in models of Alzheimer's and Parkinson's diseases. Animal studies have also confirmed that carnosine exerts a protective effect against sepsis-induced acute kidney injury.
These characteristics endow carnosine with broad application prospects in fields such as metabolic health, gut repair, liver protection, and the adjunctive treatment of neurodegenerative diseases, making it well-suited for the development of functional foods or dietary supplements targeting chronic inflammation and immune modulation.
Antioxidant Function
L carnosine powder exerts its antioxidant and anti-inflammatory effects through multiple mechanisms, directly targeting the root causes of oxidative aging. It not only efficiently chelates transition metal ions and potently scavenges reactive oxygen species and free radicals, but also actively stimulates the skin's and body's endogenous antioxidant enzyme systems. Its unique "detoxification" mechanism precisely eliminates toxic carbonyl compounds (such as the reactive aldehyde HNE) from the body, thereby interrupting the chain reactions of damage triggered by lipid peroxidation; furthermore, by modulating macrophage activity, it comprehensively alleviates inflammation. These characteristics position carnosine as a highly promising natural active ingredient with immense potential in the fields of functional foods and pharmaceuticals.
What Is l Carnosine Powder Used For?
L Carnosine Supplement
L-Carnosine dietary supplements have demonstrated therapeutic value across various clinical domains. Studies indicate that carnosine supplementation can lower fasting blood glucose, glycated hemoglobin (HbA1c), and triglyceride levels in patients with Type 2 diabetes, while also improving insulin resistance. In the realm of cardiovascular health, it enhances exercise tolerance and quality of life for patients with chronic heart failure. Regarding neuroprotection, it aids in improving cognitive function in individuals with mild cognitive impairment. Furthermore, carnosine helps mitigate diabetic nephropathy, delay age-related decline in muscle function, accelerate post-exercise muscle recovery, and counteract systemic oxidative stress. It serves as an effective form of adjunctive nutritional support for metabolic, cardiovascular, and neurodegenerative diseases.
N-acetyl-l-carnosine eye drops
L-carnosine is internationally recognized as a core active ingredient for lens protection. In pharmaceutical and clinical formulations, it is widely utilized in its acetylated prodrug form: N-acetyl-L-carnosine (NAC). While ordinary carnosine struggles to penetrate the cornea following topical application, NAC, owing to its superior lipophilicity and enzymatic stability, can effectively enter the interior of the eye and undergo gradual hydrolysis to release active carnosine. Through its potent anti-glycation and antioxidant properties, the released carnosine scavenges reactive carbonyl species (RCS) within the lens and chelates transition metal ions, thereby safeguarding lens proteins against oxidative modification. As a key raw material for NAC eye drops, L-carnosine is extensively employed throughout the ophthalmic industry.
L carnosine for skin
L-Carnosine is a key anti-aging ingredient in premium skin care formulations. Its low molecular weight enables deep skin penetration, where it exerts both anti-glycation and antioxidant effects. L-Carnosine helps protect collagen from cross-linking, preserves skin elasticity, reduces dullness, and minimizes fine lines. When combined with complementary antioxidants such as vitamins C and E, L-Carnosine creates a synergistic effect, significantly enhancing the overall anti-aging performance of creams and serums.
L Carnosine Powder Side Effects
Carnosine supplementation (2 grams daily for 14 weeks) demonstrates a favorable safety profile. No side effects associated with carnosine supplementation were observed in previous clinical trials. L carnosine powder is an over-the-counter dietary supplement that has demonstrated good tolerability in both animal and human studies. The carnosine utilized in this study possesses a purity exceeding 99.5% and is odorless, crystalline, and fully synthetic.
To ensure safety, participants with conditions or habits that could potentially confound the results, such as severe obesity, smoking, heavy alcohol consumption, use of anti-inflammatory medications, or severe renal, cardiovascular, or psychiatric disorders, were excluded. Overall, no significant adverse events were observed with carnosine at the recommended dosage.
L Carnosine Powder Dosage
The daily dosage range for l carnosine powder is 500 mg to 2 g, taken orally in divided doses; treatment courses typically last 8 to 12 weeks and are aimed at improving diabetic parameters, cognitive function, and conditions associated with neurodegenerative diseases. The standard dosage for beta-alanine is 2.4 to 6 g per day, used to enhance muscle strength and physical performance in the elderly. Additionally, when used for the treatment of oral mucositis and for gastrointestinal protection, zinc-carnosine (Polaprezinc) is administered at a daily dosage of 68 to 500 mg, which may be taken as lozenges or used as a mouthwash.
Where To Buy L Carnosine Powder?
Kintainutri® holds ISO22000 certification and maintains a comprehensive quality inspection system, ensuring that every batch of products undergoes rigorous testing via HPLC and ICP-MS. If you are seeking a compliant and reliable supplier of L-carnosine powder, we invite you to consult with us. As a primary source manufacturer of L-carnosine and botanical extracts, Kintainutri® provides carnosine powder with a consistent purity of 98–99%. We exercise complete autonomous control over the entire production chain, from raw materials to finished goods, to deliver carnosine powder with exceptional cost-effectiveness and a stable supply. If you require bulk purchasing, please do not hesitate to contact us!
*Kintainutri® Promise All Products: Non-Irradiated / Non-ETO/ Treat by Heat Only / Non-GMO
Reference:
[1]: https://www.sciencedirect.com/science/article/abs/pii/S1756464619302439
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6627134/
[3]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6464029/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC5588946/
[5]: https://pmc.ncbi.nlm.nih.gov/articles/PMC10096773/
[1]: https://www.sciencedirect.com/science/article/abs/pii/S1756464619302439
[2]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6627134/
[3]: https://pmc.ncbi.nlm.nih.gov/articles/PMC6464029/
[4]: https://pmc.ncbi.nlm.nih.gov/articles/PMC5588946/
[5]: https://pmc.ncbi.nlm.nih.gov/articles/PMC10096773/
FAQ
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